直立悬钩子的化学成分研究

Chemical Constituents from Rubus stans

目的:研究直立悬钩子的化学成分。方法:采用硅胶柱层析、Sephadex LH-20柱等色谱方法进行分离纯化,并根据理化性质及波谱数据分析等手段鉴定化合物的结构。结果:从直立悬钩子全草95%乙醇提取物中分离得到11个化合物,分别鉴定为:β-谷甾醇(1)、白桦脂酸(2)、蔷薇酸(3)、熊果酸(4)、科罗索酸(5)、山柰酚(6)、槲皮素(7)、2α,3β,19α,23-四羟基-乌苏-12-烯-28-酸(8)、β-胡萝卜苷(9)、槲皮素-3-O-β-D-葡萄糖苷(10)、山柰酚-3-O-β-D-6-O-(对羟基桂皮酰基)-吡喃葡萄糖苷(11)。结论:所有化合物均为首次从该植物中分离得到。

Objective： To study the chemical constituents of Rubus stans. Methods： The chemical constituents were isolated and purified by silica gel and Sephadex LH-20 column chromatography. The structures were identified on the basis of spectroscopic analysis and physicochemical properties. Results： Eleven compounds were isolated and purified from the ethanol extract of Rubus stans. They were identified as β-sitosterol（ 1）,betulinic acid（ 2）,euscaphic acid（ 3）,ursolic acid（ 4）,corosolic acid（ 5）,kaempferol（ 6）,quercetin（ 7）,2α,3β,19α,23-tetrahydroxy-urs-12-en-28-oic acid（ 8）,β-daucosterol（ 9）,quercetin-3-O-β-D-glucoside（ 10） and kaempferol-3-O-β-D-6-O-（ p-hydroxycinnamoyl）-glucopyranoside（ 11）. Conclusion： All the compounds are isolated from this plant for the first time.