人参三醇组皂苷对大鼠坐骨神经急性损伤后修复的研究

Study on panaxtrol saponin induced on the sciatic nerve repair of acute injury in rats

目的探讨人参三醇组皂苷(PTS)对大鼠坐骨神经急性损伤后的保护作用。方法建立大鼠坐骨神经挤压伤模型,随机分为PTS 100、50、25 mg/kg剂量组(每组10只),坐骨神经损伤后每日腹腔注射PTS;模型对照组(10只),坐骨神经损伤后每日给予同样剂量的生理盐水;空白对照组(10只),不损伤坐骨神经,每日给予同样剂量的生理盐水。坐骨神经损伤术后1、2、3、4 w观察坐骨神经功能指数(SFI)、运动神经传导速度(MNCV)。结果坐骨神经损伤术后21、30 d PTS 100 mg/kg bw剂量组的SFI分别为-30.2±10.4及-20.0±6.9明显优于模型对照组-52.1±11.0及-46.2±7.8(P<0.05),术后30 d PTS 100 mg/kg bw剂量组的MNCV为14.72±4.34明显优于模型对照组8.27±2.53(P<0.05)。结论人参三醇组皂苷对大鼠坐骨神经急性损伤后有一定的保护作用。

Objective To investigate the protective effects of panaxatriol saponins（ PTS） on acute sciatic nerve injury. Methods The rats sciatic nerve crush injury were randomly divided into PTS 100,50,25 mg / kg dose group,daily intraperitoneal injection after sciatic nerve injury panaxatriol saponins; model group,after sciatic nerve injury given the same daily dose of saline control group,no damage to the sciatic nerve,given the same dose of saline daily. 1,2,3 and 4 weeks after sciatic nerve injury was observed sciatic functional index（ SFI）,motor nerve conduction velocity recovery rate（ MNCV）. Results The sciatic nerve injury in 21,30 days after the PTS 100 mg/kg bw dose group of SFI（- 30. 2 ± 10. 4,- 20. 0 ± 6. 9） was significantly better than the model control group of SFI（- 52. 1 ± 11. 0,- 46. 2 ± 7. 8）（ P〈0. 05）,The sciatic nerve injury in 21,30 days after the PTS 100 mg / kg bw dose group of MNCV（ 14. 72 ± 4. 34） was significantly better than the model control group of MNCV（ 8. 27 ± 2. 53）（ P〈0. 05）. Conclusion PTS on rats acute sciatic nerve injury has a protective effect.