赖氨酰氧化酶样蛋白－2与肿瘤

Lysyl Oxidase-Like 2 Protein and Tumor

赖氨酰氧化酶样蛋白－2（ lysyl oxidase－like 2 protein， LOXL2）在细胞外主要参与胶原蛋白与弹性蛋白之间的交联作用。 LOXL2的功能很广泛，除了维持细胞间的稳定性，还参与了肿瘤的形成及侵袭转移过程。肿瘤的发生发展是一个多因素、多机制的复杂过程，深入研究LOXL2在肿瘤之间的作用机制具有重要的临床意义。

Lysyl oxidase-like 2 protein （LOXL2） is mainly involved in extracellular crosslink-ing between collagen and elastin.LOXL2 has extensive functions.It not only maintains the intercellu-lar stability, but also participates in the tumor formation, invasion and metastasis.The development of tumor is a complex process, involving many factors and mechanisms.In-depth study on the mech-anism of LOXL2 in tumors is of important clinical significance.