糖蛋白质组学的信息学资源和方法

Bioinformatic Resources and Methods for Glycoproteomics

糖基化修饰是生物体内最常见、最重要的蛋白质翻译后修饰之一.哺乳动物体内超过50%的蛋白质都会发生糖基化修饰.糖蛋白广泛分布于各种组织的细胞膜表面,执行着重要的生物学功能.随着高通量、高灵敏度和高分辨率的蛋白质组学时代的来临,许多基于串级质谱技术解析糖链结构的生物数据库和分析软件也亦应运而生.本文综述了目前文献中最常用的糖类生物信息学资源,包括各种糖蛋白的数据库以及质谱解析糖类的相关工具和新技术、新方法.

Glycosylation is one of the most common and important post-translational modifications（PTMs） of proteins in living organisms. More than 50% proteins are glycosylated among mammals. Glycoproteins are widely distributed in cell membrane surface and body fluids, and play critical roles in biological processes. With the rapid development of biological mass spectrometry technique, as well as biological database and analysis software for glycan structure elucidation, glycoproteomics research field is booming soon. This article summarized the most commonly used bioinformatic resources in literatures, including new developed databases, MS technique and methods.