梅州市HIV/AIDS患者接受HAART后CD4^+ T淋巴细胞变化

Changes in CD4^+ T lymphocytes of patients with HIV / AIDS receiving highly active antiretroviral therapy in Meizhou,Guangdong

目的了解梅州市接受HAART治疗的HIV/AIDS患者的CD4^+T细胞变化及影响因素,建立健全本地区HIV/AIDS患者CD4^+T淋巴细胞监测平台,为取得更好的治疗效果提供数据支持。方法调查并随访66例梅州市本地加入免费HAART治疗的HIV/AIDS患者,利用流式细胞术检测患者CD4^+T淋巴细胞水平,比较HAART治疗患者治疗前后CD4^+T数值的变化情况,进行统计学分析。结果经HAART治疗3个月以后,患者的CD4细胞有不同程度增高。同治疗基线CD4^+T细胞数目相比,治疗3、6、9、12和15个月后CD4^+T细胞平均数显著升高,分别增加110、128.9、143.2、108.4和190.8个(均为P<0.05)。治疗后,女性患者CD4^+T细胞平均数提高幅度大于男性。各年龄组CD4^+T细胞平均数升高趋势不同。结论接受HAART治疗可不同程度的提高HIV/AIDS患者CD4^+T细胞数目。CD4^+T细胞数目升高情况受性别、年龄和治疗时间影响。定期监测CD4^+T细胞计数的变化,有助于医生了解HIV/AIDS患者的病情发展和选择正确的治疗方案。

Objective To investigate changes in CD4^＋T cells of patients with HIV / AIDS receiving highly active antiretroviral therapy（ HAART） in Meizhou,Guangdong province in China. Methods The study was carried out among the patients with HIV / AIDS who received HAART therapy in Meizhou. The CD4^＋T cells of patients with HIV / AIDS were analyzed by cytometry and the profile of CD4^＋T cells were compared among patients before or after receiving the HAART regimens. Results The level of CD4^＋T cells of 66 patients withHIV / AIDS increased in different degree three months after antiviral therapy. Compared with the baseline level,the population of CD4^＋T of patients with HIV / AIDS significantly increased 3,6,9,12 and 15 months after antiviral treatment,with the numbers of CD4^＋T,110（ P = 0. 000 5）,128. 9（ P = 0. 000 4）,143. 2（ P = 0. 000 1）,108. 4（ P = 0. 001 6） and190. 8（ P = 0. 001 1）,respectively. It was shown that the numbers of CD4^＋T of female patients with HIV / AIDS were higher than those of males. Furthermore,the level of CD4^＋T increased in different upward trends in different age groups. Conclusion CD4^＋T cells count in patients with HIV / AIDS increases gradually at different therapy phase after receiving HAART treatment. However,CD4^＋T population dynamics was affected by factors,such as sex,age and times of therapy.Regular monitoring of changes in CD4^＋T cell count of patients with HIV / AIDS helps doctors understand the patient’s course of disease and select the correct regimens.