绵阳地区献血人群HBV流行率和新发率调查分析

Investigation on the HBV prevalence status among blood donors in Mianyang

目的计算和分析绵阳地区献血人群2008年1月-2010年12月HBV的流行率、新发率,评估HBV在绵阳地区的献血人群中的流行情况。方法收集2008年1月-2010年12月100 429人次献血者人口统计学资料、ELISA试剂初筛和确证实验数据。计算初次献血者和重复献血者的HBV流行率,进一步评估重复献血人群中HBV的新发率。结果 2008年1月-2010年12月绵阳地区初次献血和重复献血人群的HBV流行率依次为0.97%和0.04%,重复献血人群中的HBV感染新发率为0.32%。结论绵阳地区献血人群具有较高的流行率和新发率,可能引起较高的HBV输血残余风险,应考虑采用第4代ELISA初筛试剂和核酸检测(NAT)降低该地区的HBV对血液安全的影响。

Objective To analyze the prevalence、incidence rate of HBV among blood donors in Mianyang from January2008 to December 2010. Methods The demographic information、parallel screening with the third generation ELISA kits and confirmatory testing results were collected from 100429 donations. The prevalence rates on first and repeat donors were calculated,as well as the incidence rates using the reported incidence evaluation model. Results During the study period,the prevalence rates among first and repeat donors were 0. 97% and 0. 04% respectively and the HBV incidence rate on repeat donors was 0. 32%. Conclusion Relative high HBV prevalence and incidence rates in Mianyang may lead to high HBV transfusion residual risk,and the fourth generation ELISA screening assays and NAT testing were suggested to be implemented reducing the impact of HBV on blood safety in Mianyang.