CDR1as与疾病的相关性

The Roles of CDR1as in Diseases

环状RNA(circular RNA,circRNA)是存在于真核细胞中的一种非线性RNA,具有稳定性、特异性以及进化保守性等特征,通过发挥microRNA的海绵作用,对其靶基因进行调控。与线性RNA相比,环状RNA自身的闭合环状结构使其更具优越性。小脑变性相关蛋白1反义转录物(cerebellar degeneration-related protein 1 antisense,CDR1as)作为一种竞争性内源RNA(competing endogenous RNA,ceRNA)间接调控miR-7靶标,通过多种途径影响多种疾病的发生和发展。本文就CDR1as的发现、来源及特征、功能以及与不同疾病的相关性作一概述。

In eukaryotic cells,circular RNA（ circRNA） is a non-linear RNA with characteristics such as high stability,specificity,and evolutionary conservation. It is found that circRNA regulates the expression of its target genes and mainly functions as microRNA sponges. Compared with the linear structure of coding RNA,the closed structure of circular RNA makes it more conserved. The cerebellar degeneration-related protein 1 antisense（ CDR1as）,a competing endogenous RNA,indirectly regulates miR-7 and is involved in the development of multiple diseases through a variety of pathways. In this paper,the discovery,origin,features,and functions of CDR1 as,as well as its related diseases were summarized.