地佐辛预先镇痛配合舒芬太尼静脉自控镇痛对结直肠癌根治术后临床效果观察

Observation on Clinical Effect of Preemptive Analgesia with Dezocine Combined with Intravenous Patient-controlled Analgesia with Sufentanil among Patients with Colorectal Cancer after Radical Resection

目的观察地佐辛预先镇痛配合舒芬太尼静脉自控镇痛对结直肠癌根治术后的临床效果。方法选取在华亭县中医医院接受结直肠癌术的90例患者作为研究对象,按照随机数字表法分为对照组和研究组,每组各45例,对照组采用舒芬太尼静脉自控镇痛,研究组在对照组的基础上配合地佐辛预先镇痛,观察两组患者术后疼痛程度、镇静程度及不良反应发生率。结果两组患者术后3 h、6 h和12 h VAS评分比较差异有统计学意义(P<0.05);术后24 h、48 h VAS评分差异无统计学意义(P>0.05),且两组数据每两个时刻比较差异有统计学意义(P<0.05)。两组患者术后3 h、6 h、12 h、24 h和48 h Ramsay评分比较差异有统计学意义(P<0.05);两组患者术后24 h、48 h较术后3 h、6 h,术后48 h较术后12 h Ramsay评分差异显著(P<0.05)。两组患者术后24 h、48 h均较术后3 h镇静效果好(P<0.05)。研究组不良反应发生率为11.11%,低于对照组的24.44%,差异有统计学意义(P<0.05)。结论地佐辛预先镇痛配合舒芬太尼静脉自控镇痛可有效改善结直肠癌根治术后疼痛程度。

OBJECTIVE To observe the clinical effect of preemptive analgesia with dezocine combined with intravenous patient-controlled analgesia with sufentanil in patients with colorectal cancer after radical resection. METHODS 90 cases of patients with colorectal cancer after radical resection in our hospital were selected, who were divided into control group and study group according to the random digital table method with 45 cases in each. The control group were treated with intravenous patient-controlled analgesia with sufentanil, while the study group were treated with preemptive analgesia with dezocine based on the control group. The pain degrees after operation, sedation degrees and incidence rates of adverse reactions in the two groups were observed. RESULTS The differences in the scores of VAS at 3 h, 6 h, 12h after operation in the two groups were statistically significant（P〈0.05）, which at 24h and 48h after operation were not statistically significant（P〉0.05）, and there were significant differences between each two moments（P〈 0.05）. The differences in the scores of Ramsay at 3 h, 6 h, 12 h, 24 h and 48 h between the two groups were statistically significant（P〈0.05）, and the scores at 24 h and 48 h after operation were significantly different from those at 3 h, 6 h after operation, as well as those at 48 h after operation from those at 12 h after operation（P〈0.05）. The incidence rate of adverse reactions in the study group was 11.11%, which was lower than that of 24.44% in the control group（P〈0.05）. CONCLUSION The preemptive analgesia with dezocine combined with intravenous patient-controlled analgesia with sufentanil in patients with colorectal cancer after radical resection could effectively improve pain degrees after operation.