老年非小细胞肺癌组织中表皮生长因子受体基因突变情况及其与切割修复交叉互补基因1表达的相关性被引量：2

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摘要目的探讨老年非小细胞肺癌(NSCLC)组织中表皮生长因子受体(EGFR)基因突变情况及其与切割修复交叉互补基因(ERCC)1表达的关系。方法选择老年NSCLC患者150例作为研究对象,采用PCR技术检测老年NSCLC组织中EGFR基因突变和ERCC1基因表达水平。结果 150例老年NSCLC组织中EGFR基因突变62例,突变率为41.3%,外显子21和外显子19突变率分别为18.7%和18.0%。老年NSCLC组织中,男性EGFR基因突变率低于女性(P<0.05),吸烟患者EGFR基因突变率低于非吸烟患者(P<0.05),腺癌患者EGFR基因突变率高于非腺癌患者(P<0.05),有肿瘤家族史患者EGFR基因突变率高于无肿瘤家族史患者(P<0.05),不同TNM分期患者EGFR基因突变率比较有差异(P<0.05)。EGFR基因突变型ERCC1高表达率低于EGFR基因野生型(P<0.05)。结论老年NSCLC患者EGFR基因突变以外显子21和外显子19突变为主,性别、吸烟、腺癌、肿瘤家族史、TNM分期为EGFR基因突变的影响因素,EGFR基因突变者ERCC1基因表达量低。

作者张利诚

机构地区武警浙江省总队嘉兴医院呼吸科

出处《中国老年学杂志》 CAS CSCD 北大核心 2016年第17期4234-4236,共3页 Chinese Journal of Gerontology

关键词非小细胞肺癌表皮生长因子受体基因基因突变

分类号 R73 [医药卫生—肿瘤]

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