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阿尔茨海默病和轻度认知障碍患者血清皮质醇水平变化及意义 被引量：3

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摘要 目的探讨阿尔茨海默病(AD)和轻度认知障碍(MCI)患者血清皮质醇水平的变化及意义。方法采集46例AD、42例MCI及44例正常对照者的外周静脉血进行血清皮质醇水平检测,所有受试者均进行简易精神状态量表(MMSE)、Hachinski缺血指数(HIS)及汉密顿抑郁量表(HAMD)评定,AD患者用临床痴呆评定量表(CDR)进行痴呆严重程度分级。结果 AD组血清皮质醇水平为(596.47±58.29)nmol/L,MCI组为(558.64±71.05)nmol/L,正常对照组为(408.65±79.86)nmol/L,AD组和MCI组均显著高于对照组(P<0.01);AD组与MCI组比较无显著差异(P>0.05)。AD组血清皮质醇水平与MMSE评分存在负相关(P<0.05)。结论 AD和MCI患者存在血清皮质醇升高,且与AD严重程度显著相关,皮质醇可能参与了AD和MCI的病理过程。
作者 胡卫红 陆光华 徐韩 丁宇杰 李霞 肖世富
机构地区 上海交通大学附属精神卫生中心老年科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2016年第17期4295-4297,共3页 Chinese Journal of Gerontology
关键词 阿尔茨海默病 轻度认知损害 皮质醇
分类号 R743 [医药卫生—神经病学与精神病学]
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参考文献16

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中国老年学杂志
2016年 第17期

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