胃癌患者营养状况与TNF-α IL-6 IFN-γ的相关性研究

Correlation on nutrition status of patients with gastric cancer and TNF-α,IL-6 and IFN-γ

目的探讨胃癌患者营养状况与肿瘤坏死因子(TNF-α)、白介素-6(IL-6)、干扰素-γ(IFN-γ)的关系。方法运用流式细胞小球微阵列术(CBA)对胃癌术前患者(胃癌组)40例和健康体检者(对照组)30例的TNF-α、IL-6、IFN-γ水平进行检测,结合临床及病理资料,分析上述指标与胃癌患者营养状况的关系。结果与对照组相比,胃癌组和有营养风险的胃癌患者TNF-α、IL-6、IFN-γ表达水平增高,差异均有统计学意义(P<0.05)。基于胃癌患者、有营养风险胃癌患者不同性别、病理类型、临床分期的分析中,TNF-α、IL-6的表达水平差异均无统计学意义(P>0.05),而胃癌患者中TNF-α与IL-6、IFN-γ显著相关,IL-6与IFN-γ显著相关。结论 TNF-α、IL-6、IFN-γ表达水平与胃癌患者营养状况有关,与性别、病理类型、临床分期无关;TNF-α、IL-6、IFN-γ可作为早期诊断胃癌营养不良的参考指标。

Objective To explore the correlation between nutrition status of patients with gastric cancer and TNF-a, IL-6 and IFN-7. Methods Cytometric Bead Array （CBA） was applied to determine TNF-a, IL-6 and IFN-7 level of gastric cancer group （40 cases） and control group（30 cases）. The relationship between nutrition status of patients with clinical and pathological data were analyzed. Results The expression level of TNF-a, IL-6 and IFN-yof gastric cancer group and gastric cancer group of nutritional risk were significantly higher than that of control group （P〈0.05）. The expression level of TNF-a and IL-6 of patients with gastric cancer with different genders, pathological patterns and clinical stages were not statistical significant different （P〉0.05）. The IL-6 and TNF-a, IFN-y among patients with gastric cancer were significant correlated. TNF-a and IFN-y were significant correlated. Conclusion TNF-a, IL-6, IFN-y are related with occurrence of malnutrition with patients with gastric cancer. The aforementioned factors can be used to assist the determination of nutritional status of patients with gastric cancer.