维吾尔族血管紧张素原基因T704C多态性与异常黑胆质型体液的关系

Relationship between the polymorphism of angiotensinogen gene T704C of Uyghur and abnormal savda

目的:探讨维吾尔族血管紧张素原(AGT)基因T704C多态性与异常黑胆质型体液的关系。方法:将维吾尔族不同异常体液人群218例分成异常黑胆质型体液组(71例)和非异常黑胆质型体液组(147例),采用聚合酶链反应-限制性片断长度多态性技术进行T704C位点多态性检测。结果:异常黑胆质型体液组和非异常黑胆质型体液组基因型分布TT、TC和CC分别为14.1%、85.9%、0%和27.9%、72.1%、0%,差异有统计学意义(P<0.05);异常黑胆质型体液组等位基因T、C频率为57.0%、43.0%,而非异常黑胆质型体液组为63.9%、36.1%,差异无统计学意义。结论:AGT基因T704C多态性可能与维吾尔族异常黑胆质型体液密切相关。

Objective：To investigate the association of polymorphism of angiotensinogen（AGT） gene T704 C with abnormal savda in Uyghur people.Methods：The total of 218 Uyghur people with different abnormal body l uids were divided in two groups：abnormal savda group 71 cases and non-abnormal savda group 147 cases and were studied by polymerized chain reaction-detection of polymorphism at site T704 C by restriction fragment length polymorphism technique.Results：In the abnormal savda group the distribution of TT,TC,CC genotypes was 14.1%,85.9%,0%,respectively and non-abnormal savda group was 27.9% 72.1%,0%;the difference was statistically significant（P〈0.05）.The frequency of allele T and C in the abnormal savda and non-abnormal savda groups was 57.0%,43.0% and 63.9%,36.1%;the difference was not statistically significant.Conclusion：The polymorphism of AGT gene T704 C might have a close association with body l uid with abnormal savda in Uyghur.