急性缺血性中风病痰热腑实证甲状腺激素变化的研究

Changes of thyroid hormone in acute ischemic stroke patients with syndrome of phlegm-heat and fu-organ excess

目的:探讨急性缺血性中风病痰热腑实证患者血清甲状腺激素的变化特点。方法:纳入符合标准的患者96例(痰热腑实证组54例,非痰热腑实证组42例)进行血清甲功5项检测,同时对痰热腑实证患者进行相关量表评价。结果:痰热腑实证组总甲状腺素(TT4)水平高于非痰热腑实证组,并与痰热腑实证成立呈正向相关(r=0.246,P<0.05)。痰热腑实证患者总三碘甲状腺原氨酸(TT3)、游离三碘甲状腺原氨酸(FT3)与年龄呈负相关(r分别为-0.440、-0.395,P<0.01),游离甲状腺素(FT4)与年龄呈正相关(r=0.303,P<0.05)。痰热腑实证组TT3降低的患者较TT3正常者阴虚证积分高(P<0.05)。结论:急性缺血性中风病患者TT4水平越高,痰热腑实证成立的可能性越大;痰热腑实证患者的甲状腺激素水平与年龄有一定的相关性。

Objective：To explore the changes of thyroid hormone in acute ischemic stroke patients with syndrome of phlegm-heat and fu-organ excess.Methods：Ninty-six qualified subjects were recruited（54 in the study group with phlegm-heat and fu-organ excess pattern,and the other 42 in the control group with no phlegm-heat and fu-organ excess pattern）.Five itemsin thyroid functions of all the subjects were tested.Related scales were conducted in the group of patients with phlegm-heat and fu-organ excess.Results：The average total thyroxin（TT4） level of the study group was higher than that of the control group with a positive correlation between the level of TT4 and syndrome of phlegm-heat and fu-organ excess（r=0.246,P〈0.05）.Negative correlations were found between age and triiodothyronine（TT3） and free triiodothyronine（FT3）,respectively（r=-0.440,-0395,P〈0.01）;a positive correlation was found between age and free thyroxin（FT4）（r=0.303,P〈0.05）;subjects with lower levels of TT3 had a higher average score of yin def iciency than subjects with normal levels of TT3（P〈0.05）.Conclusion：Acute ischemic stroke patients with higher level of TT4 are more likely to develop the syndrome of phlegm-heat and fu-organ excess.The levels of thyroid hormones of acute ischemic stroke patients with this syndrome have certain correlation with age.