摘要
自从γH2AX在1998年首次发现以来,迅速成为多个学科领域的研究热点和研究工具。针对γH2AX建立的多种先进检测方法在生命科学和医学等多个领域内的应用展现了发展潜力。本文从其磷酸化和去磷酸化机制,各种检测分析技术的发展和建立,以及在相关领域里的应用进展等三个方面进行了综述。
Since γH2AX was firstly found in 1998 , it has been one of the most important scientific topics and research tools in the related scientific fields. At present, a series of advanced testing methods and analytical technologies have been developed, which exhibited a quite attractive application prospect in the area of life science and medical science. This paper reviewed the latest progress about γH2AX in terms of molecular mechanism of phosphorylation/dephosphorylation, development of testing technologies, and the related applications.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
2016年第8期1291-1299,共9页
Chinese Journal of Analytical Chemistry
基金
国家自然科学基金资助项目(No.21347002)~~
关键词
γH2AX
磷酸化
免疫荧光技术
毒理学评价
综述
γH2AX
Phosphorylation
Immunofluoreseence technology
Toxicity evaluation
Review
