血浆瘦素水平与首发抑郁症临床症状的相关性研究

Correlation study on plasma leptin level and clinical symptoms of first episode depression

目的研究瘦素水平与首发抑郁症临床症状之间的相关性。方法选取40名首发抑郁症患者（2015年3～10月在湖州市第三人民医院心身科住院）作为病例组，通过汉密尔顿量抑郁量表（HAMD）测评临床症状，以40名健康人群作为对照组，两者均为男女各20例，测两组患者的血浆瘦素水平。结果（1）不同性别的血浆瘦素水平具有统计学差异，女性血浆瘦素水平要高于男性血浆瘦素水平（P〈0,05）。病例组的血浆瘦素水平高于对照组，两者有统计学差异（P〈0．05）。（2）病例组的血浆瘦素水平与HAMD总分呈正相关（r=0．746，P〈0．05）。（3）病例组的血浆瘦素水平和HAMD的下列因子呈正相关：焦虑／躯体化因子（r=0．415，P〈0．05），睡眠障碍因子（r=0．409，P〈0．05）。结论（1）女性的血浆瘦素水平要高于男性的血浆瘦素水平。（2）首发抑郁症患者的血浆瘦素水平要高于健康人群，瘦素水平越高，抑郁程度越重。

Objective To study the correlation of plasma leptin level and clinical symptoms of first episode depression. Methods 40 patients with first episode depression hospitalized in Psychosomatic Department of Huzhou Third People＇s Hospital were selected as case group. Clinical symptoms were evaluated by Hamilton Depression Scale （HAMD）. 40 cases of healthy people were selected as control group. Both case group and control group were male and female 20 cases. Plasma leptin levels of the two groups were measured. Results （1） Plasma leptin levels were statistically different in different genders. Plasma leptin levels in women were higher than those in men （P 〈 0.05）. Plasma leptin levels in case group were higher than those in control group. There were statistical differences between the two （P 〈 0.05）. （2） The plasma leptin level was positively correlated with the total score of HAMD in case group （r=0.415, P 〈 0.05）. （3） The plasma leptin level in case group was positively correlated with the following factors of HAMD： anxiety / somatic factor （r=0.415, P 〈 0.05）, sleep disturbance factor （r=0.409, P 〈 0.05）. Conclusion （1） Plasma leptin levels in women are higher than those in men. （2） Plasma leptin levels of patients with first episode depression are higher than those of health people with the higher the leptin level, the more severe the degree of depression.