临床常用保护肾功能药物研究进展

Research progress on clinical commonly medicines for renal function protection

肾脏疾病在临床十分常见,改善肾脏功能是预防和治疗肾脏疾病的主要方式之一。目前临床常用保护肾脏的药物主要有HMG-CoA还原酶抑制剂、血管紧张素转换酶抑制剂、血管紧张素Ⅱ受体拮抗剂、钙通道阻滞剂、前列腺素、卡培立肽和阿司匹林,其机制与降低血脂、改善内皮的功能、减缓肾间质炎症和纤维化过程、抑制尿蛋白的重吸收、降低血压和改善血流动力学等有关。然而应该注意到这些药物使用不当也可能引起肾功能损害,因此必须严格按照其适应症、疗程和剂量合理使用才可以充分发挥其肾功能保护作用。

Kidney disease was common in clinic, while improving renal function was one of the main ways of the prevention and treatment of kidney disease. At present, the clinical commonly medicines for renal function protection included HMG-CoA reductase inhibitor, angiotensin converting enzyme inhibitor, angiotensin Ⅱ receptor antagonist, calcium channel blocker, prostaglandin, earperitide and aspirin. The mechanisms of those medicines were involved in lowering blood lipid, improving endothelial function, slowing down the process of renal interstitial inflammation and fibrosis, inhibiting the urine protein reabsorption, lowering blood pressure and improving hemodynamics. However, we should notice that improper use of these medicines could also cause kidney function damage. Therefore, we should be in strict accordance with the indications, course and the dose of those medicines for realizing their protection of renal function.