280例乳腺癌患者内分泌治疗用药依从性分析

Analysis of Medication Compliance on Endocrine Therapy in 280 Breast Cancer Patients

目的:为提高乳腺癌患者用药依从性提供参考。方法:抽取某院乳腺科化疗病区2015年9-11月曾行内分泌治疗的晚期乳腺癌住院患者280例,采用问卷调查和现场访谈相结合的方式,对其内分泌治疗的用药依从性及影响因素、内分泌治疗药物致不良反应等情况进行调查分析。结果:280例患者中,用药依从性良好、一般及较差的患者分别有161例(57.5%)、64例(22.9%)和55例(19.6%);其用药依从性主要受"认为疾病已控制(27.2%)""药品不良反应(22.4%)""忘记服药(21.1%)"等因素的影响;内分泌治疗药物常见的药品不良反应包括潮热、情绪异常和关节痛等。结论:临床药师尤其是专科临床药师应充分发挥自身专业优势,加强患者的用药教育,积极参与查房和随访工作,提高乳腺癌患者内分泌治疗的用药依从性。

OBJECTIVE：To provide reference for improving the breast cancer patients＇ medication compliance. METHODS：280 inpatients with advanced breast cancer who had received endocrine therapy in a hospital ward of chemotherapy of breast from Sept. to Nov. 2015 were selected,questionnaires was combined with on-site interview to investigate and analyze the medication compliance,influential factors and adverse reactions induced by endocrine drugs. RESULTS：Among the 280 patients,161（57.5%）showed good medication compliance,64（22.9%）were general and 55（19.6%）were poor;its medication compliance were mainly affected by＂wrong understanding on disease control（27.2%）＂＂adverse drug reactions（22.4%）＂＂forgetting taking medicines（21.1%）＂;the common adverse reactions of endocrine therapy included hot flashes,mood disorders and joint pain. CONCLUSIONS：Clinical pharmacists,especially the specialists should give full play to their own professional advantage,strengthen patient medication education,actively participate ward round and follow-up,improve breast cancer patients＇ compliance on endocrine therapy.