肿瘤坏死因子α拮抗剂所致药物性狼疮1例并文献复习

Clinical Prevention and Intervention Effect of Shenqi Decoction on Coronary Restenosis of Coronary Heart Disease After PCI

目的探讨肿瘤坏死因子a拮抗剂所致药物性狼疮的临床特征和发病机制。方法：通过报告1例重组人II型肿瘤坏死因子受体抗体融合蛋白所致药物性狼疮病例并进行文献复习，总结此种药物性狼疮的临床特征及可能的发病机制。结果：该病特点：女性好发；急性皮疹、大脑、肾脏损伤的发生率更高；抗ds—DNA抗体阳性率高；低补体血症更常见。发病机制尚不明确。结论：肿瘤坏死因子α拮抗剂所致药物性狼疮不同于普通的药物性狼疮，一旦发现可疑患者，应及早停药并给予积极治疗。

Objective：To observe the clinical prevention and intervention effect of Shenqi decoction on coronary restenosis of pa-tients with coronary heart disease after PCI.Methods：A total of 218 patients with coronary heart disease treated in this hospital were divided into the research group and control one according to the random number table,with 109 cases in each group.Patients in the control group were given the routine western medicine therapy;while patients in the research group were given the treatment of Shenqi decoction in addition to the routine western medicine therapy.The changes of TCM syndrome scores and changes of in-flammatory markers before and after the treatment and incidence of coronary restenosis were compared between two groups.Re-sults：The magnitude of decrease in qi deficiency symptom score and blood stasis syndrome score of patients at 3 months and 6 months after taking the medicine in the research group were significantly better than those in the control group （P 〈0.05）.The levels of high-sensitivity C-reactive protein,activated T lymphocytes and soluble interleukin-2 receptor at 3 months and 6 months af-ter the treatment the treatment in the research group were significantly better than those in the control group （P 〈0.05）.The inci-dence of restenosis for patients in the research group was 17.43%,which was significantly lower than 34.86% of control group （P〈0.05）.Conclusion：The application of Shenqi decoction in the coronary heart disease after PCI can significantly improve the TCMsyndrome scores of patients,inhibit the chronic inflammatory state,enhance the immunity levels and reduce the risk of coro-nary restenosis.