Oct-4蛋白在甲状腺肿瘤中的表达及意义

Professor Lin Hongshengs Lung Cancer Syndrome Differentiation and Treatment Experiences

目的对Oct-4蛋白在甲状腺肿瘤中的表达及意义进行探讨。方法：对甲状腺腺瘤15例、甲状腺乳头状癌30例、髓样癌3例、甲状腺滤泡状癌2例采用免疫荧光法进行检测，观察其Oct-4表达。结果：几种甲状腺肿瘤中，0ct-4均有表达。在甲状腺髓样癌与滤泡癌中Oct-4的表达水平最高：Oct-4在甲状腺乳头状癌中的表达明显高于在甲状腺腺瘤中的表达，其表达与患者性别、年龄、肿块大小、位置及转移等没有显著相关。结论：甲状腺组织中可能存在Oct-4阳性细胞，与甲状腺肿瘤的形成可能有关；甲状腺癌中的0ct-4表达水平明显高于良性甲状腺肿瘤；Oct-4阳性细胞在甲状腺滤泡癌、髓样癌中的残留较多，这与肿瘤恶性程度较高的特点是相同的。

Objective To Oct 4 protein expression in thyroid tumors and significance axe discussed. Methods： 15 case＇s of thyroid adenoma and thyroid papillary carcinoma （30 cases, medullary carcinoma （3 cases）, thyroid follicular carcinoma, 2 cases by immunofluorescence method for testing the Oct-4 expression was observed. Results： In several kinds of thyroid tumors, Oct-4 all by express. In the medullary thyroid carcinoma and follicular carcinoma Oct-4 highest expression level; Oct-4 expression was significantly higher in papillary thyroid carcinoma in thyroid adenoma of expression, the expression and the patient＇s gender, age, tumor size, location and transfer, etc. No significant correlation. Conclusion：Thyroid tissue that may exist in the Oct-4 positive cells, and thyroid tumor formation may be related to; thyroid cancer of Oct-4 expression levels were significantly higher than benign thyroid tumor; Oct-4 positive cells in thyroid follicular carcinoma, medullary carcinoma more residual and the features with high degree of malignancy is the same.