辛伐他汀改善大鼠急性心肌梗死后缺血后适应的机制研究

目的研究辛伐他汀改善大鼠急性心肌梗死后缺血后适应的机制。方法：选雄性Wistar大鼠27只，随机分3组并予以相应的治疗，4周后麻醉大鼠活体取出心脏，术前术后分别测定心肌组织及血液内HIF—1α和eNOS、iNOS表达。结果：辛伐他汀干预组心肌梗死面积明显小于单纯心肌梗塞组。辛伐他汀干预组明显增加心肌组织和血清内HIF-1α、eNOS、iNOS表达（P〈0．05）。结论：辛伐他汀改善大鼠急性心肌梗死后心室重塑，可能与增加HIF-1α、eNOS、iNOS的表达、改善缺血后适应等机制有关。

Objective To investigate the effect of simvastatin improve ischemia after acute myocardial infarction in rats after adaptation mechanism. Methods： 27 male Wistar rats, were randomly divided into three groups. 4 weeks after anesthesia in rats in vivo to remove the heart and rat myocardial infarct size measurement, pathological changes, ventrieular remodeling, preoperative postoperative were measured in myocardial tissue and blood of HIF-1 alpha and en OS. The expression of iNOS. Results：Simvastatin intervention group, the myocardial infarct size was significantly lower than that in simple myocardial infarction group.Simvastatin intervention group increased obviously in myocardial tissue and serum of HIF-1 alpha, eNOS, iNOS expression （P〈 0.05）. Conclusion： The improved by simvastatin in rats with acute myocardial infarction ventricular remodeling after, may be associated with increased HIF-1 alpha, eNOS, I The expression of NOS is related to improving the mechanism of ischemic adaptation and so on.