药品不良反应报告分析

目的分析本院药品不良反应ADR的发生情况，为临床合理用药提供参考。方法：对225份ADR报告进行回顾性统计分析。结果：发生ADR患者中，女性多于男性，但其差异无统计学意义，60岁以上患者ADR发生率高于其他年龄段。抗菌药物引发的不良反应143例，所占比例最高（63．6％），其中喹诺酮类不良反应为25．49％，头孢菌素类22．4％。静脉给药是导致ADR的主要给药途径。临床表现以皮肤及附件损伤最常见（29．3％），所有ADR均治愈或好转。结论：临床应了解并重视ADR的监测和上报工作，完善相关报告分析制度，确保临床用药安全、有效、合理。

Objective To investigate the incidence of adverse drug reaction of ADR in our hospital,so as to provide references for rational drug use. Methods：The 265 case of ADR reports were analyzed retrospectively. Results：In the cases,the incidence for males was higher than for females, no significant gender difference was observed, population over 60 accounted for the largest proportion （26.2%）. In the total 225 ADR cases, induced by antibacterial drugs ranked first （63,6%）, quinolane class adverse reaction was 25.49%, cephalosporin class adverse reaction was 22.4%. Intravenous infusion was the easiest way to led to ADRs （76.4%）. Cases of lesions of skin and its appendages were the roost common （29.3%）, all ADRs were cured or improved. Conclusion：The ADR reporting and analyzing system should ensure clinical safe,effectlve and rational use of drugs.