维吾尔族非霍奇金淋巴瘤遗传学研究及其临床意义

目的分析维吾尔族非霍奇金淋巴瘤遗传学特征。方法：收治93例维吾尔族NHL病例，分析其染色体核型异常状况，重新复检HE切片，应用免疫组织化学p-V9000二步法标记CD20、CD45R0、CD30、CD15抗体，结合临床病理特征及免疫组织化学染色结果进一步分型，将93例维吾尔族NHL病例随机的分为CHOP治疗组和R-CHOP治疗组，CHOP组治疗46例患者，R-CHOP组治疗47例。结果：93例新疆维吾尔族NHL病例男女比例为1．91：1，发病平均年龄44．54岁，发病部位结内54例，结外39例，B细胞性淋巴瘤76例，占绝对优势，多数的患者伴有染色体核型异常，且染色体累及较多，主要部位有3q27异常和13q10异常，治疗效果方面，CHOP组5年内的生存患者为16人（34．8％），R-CHOP组5年内的生存患者为26人（55．4％）；结论：维吾尔族NHL的发病患者中，男性多于女性，年纪较小，发病部位以结内多见，最常见组织学类型依次为弥漫性大B细胞淋巴瘤、滤泡性淋巴瘤、黏膜相关淋巴组织的结外边缘区B细胞淋巴瘤，并且多数伴有累及多条染色体的核型异常，异常类型多为3t127异常和13qi0异常。

Objective To analyze Uygur NHL genetic characteristics; Methods： A hospital in March 2013 - the clinical data Uygur NHL cases of 93 patients admitted in September 2015 to analyze the karyotype abnormalities re-re-examination HE sections, immunohistochemical two-step P-vg000 marker CD20, CD45RO, CD30, CD15 antibody, combined with clinicopathological features and immunohistochemical staining results further classification, 93 patients randomized Uygur NHL divided into a treatment group and CHOP R-CHOP group therapy, CHOP group treated 46 patients, R-CHOP group treated 47 patients; Results： 93 cases of NHL cases in Xinjiang Uygur male to female ratio was 1.91： 1, the average age of onset 44.54 years, disease location within the knot 54 cases, 39 eases of extranodal, B-cell lymphoma, 76 cases dominant, majority of patients with abnormal karyotype and chromosome involving more major parts of 3q27 and 13q10 abnormalities abnormalities, treatment aspects, CHOP group of patients survive five years was 16 （34.8%）, R-CHOP group of patients survive five years was 26 （55.4%）; Conclusion： the incidence of NHL in patients Uighur men than female, younger, the incidence of nodal sites were more common, the most common histological types were diffuse large B-cell lymphoma, follicular lymphoma, mucosa-associated lymphoid tissue extranodal marginal zone B-cell lymphoma, and most associated with muhisystem chromosome karyotype abnormality, abnormality mostly 3q27 and 13q10 abnormalities abnormalities.