当归四逆汤治疗系统性硬化症的疗效及对生存质量的影响

The efficacy and quality of life of Danggui Sini Tang for patients with systemic sclerosis

目的观察当归四逆汤治疗系统性硬化症的临床疗效及对患者生存质量的影响。方法将60例系统性硬化症患者随机分为当归四逆汤组、当归四逆汤+青霉胺组及青霉胺组,每组20例,分别给予相应药物治疗2个月。观察3组治疗前后Steen评分、生存质量评分及不良反应发生情况。结果治疗后3组Steen评分均明显降低(P均<0.05),生存质量评分均明显升高(P均<0.05),且当归四逆汤组和当归四逆汤+青霉胺组改善情况均明显优于青霉胺组(P均<0.05),当归四逆汤+青霉胺组改善情况均明显优于当归四逆汤组(P均<0.05);当归四逆汤组+青霉胺组的不良反应发生率明显低于青霉胺组(P<0.05)。结论当归四逆汤可有效改善系统性硬化症患者的临床症状,提高患者生存质量,且无明显不良反应,与青霉胺联用,可提高疗效,并减轻西药不良反应,缓解患者身心痛苦。

Objective It is to observe the influence of Danggui Sini Tang（DGSNT） on the clinical efficacy and quality of life of patients with systemic sclerosis.Methods 60 patients with systemic sclerosis were randomly divided into DGSNT group,DGSNT ＋ penicillamine group and penicillamine group.Every group have 20 cases and all patients were received the corresponding treatment for 2 months.The Steen scores,quality of life scores before and after treatment and the adverse effects of the three groups were analyzed.Results After treatment,the Steen scores of all groups were significantly reduced（all P 〈0.05）,and the quality of life scores of all groups were significantly increased（all P 〈 0.05）,and the improvement of the DGSNT ＋ penicillamine group and the penicillamine group were significantly better than that of the control group（all P 〈0.05）,and those of the DGSNT ＋ penicillamine group were significantly better than the penicillanmine group（all P 〈 0.05）.The adverse reactions Incidence of the DGSNT ＋ penicillamine group was significantly lower than that of the penicillamine group（P 〈0.05）.Conclusion DGSNT can effectively improve the clinical symptoms,improve the quality of life of patients with systemic sclerosis and have no significant adverse reactions.DGSNT combine with penicillamine can improve the efficacy,reduce the side effects of Western medicine and alleviate the pain and suffering of patients.