小儿新月体肾炎12例临床和病理分析

目的探讨小儿新月体肾炎的临床症状和病理情况。方法：选取新月体肾炎的小儿12例，分为两组，I组8例和II组4例，经过B超检测后进行肾脏穿刺活检术，观察其组织的病理情况，采用甲泼尼龙进行治疗，观察小儿的临床疗效。结果：经过检查后，lO例抗。肾小球基底膜（GBM）肾炎呈现阴性，2例呈现阳性。治疗后，I组患儿的肾小管萎缩间质纤维化、肾小球球性硬化以及间质炎细胞浸润比例显著优于II组，存在差异性（P〈0．05）。I组患儿显效3例，有效3例，总有效率为75％，II组患儿显效1例，有效1例，总有效率为50％，I组患儿总有效率显著优于Ⅱ组，存在显著差异（P〈0．05）。结论：临床上小儿新月体肾炎是比较常见的一种小儿疾病，需要及时进行肾活检术，掌握病情的发展情况，并给与一定的治疗，也可进行有效地预防措施，增强患儿的。肾功能。

objective to investigate the crescent nephritis clinical symptoms and pathological conditions. Selection methods： our hospital in 2012-2013 12 caseswith crescent nephritis in children, have kidney disease, according to the characteristics of the condition, divided into two groups,I 8 cases and 11 group 4 cas-es, after B ultrasonic examination on the kidney biopsy, observed the pathological situation of its organization, using a prednisolone treatment, observe the clinicalcurative effect of infantile. Results： after check in children with 12 cases, 10 cases of anti glomerular basement membrane （GBM） nephritis is negative, 2 cases ofGBM nephritis in children with positive. After treatment, I group of children with renal tubular atrophy fibrosis, glomerular sclerosis and interstitial inflammatorycell infiltration ratio significantly better than the II group, exist difference （P〈0．05）, with statistical significance. I group of children were in 3 cases, 3 cases ef-fectively, the total effective rate was 75%, lI group of children were in 1 case, 1 case effectively, the total effective rate was 50%, I group total effective rate wassignificantly better than lI children with total effective rate, there are significant differences （P〈0.05）, with statistical significance. Conclusion： clinical pediatriccrescent nephritis is a kind of common pediatric disease, need for renal biopsy in time, grasp the development situation of the disease, and give treatment, can alsobe effectively preventive measures, strengthen the patient＇s kidney function.