艾塞那肽与胰岛素强化治疗肥胖2型糖尿病40例疗效分析

目的观察40例血糖控制欠佳的肥胖2型糖尿病患者应用艾塞那肽及胰岛素强化治疗12周后的临床疗效。方法：选取40例血糖控制欠佳的肥胖2型糖尿病患者，分别应用艾塞那肽及胰岛素强化降糖治疗12周。结果：治疗4及12周后，艾塞那肽组与胰岛素组较治疗前相比FPG、OGTT 2hPG，HbAlc均下降，空腹c肽均升高，且具有统计学差异（P〈0．05）。但两组上述指标并无统计学差异（P〉0．05）。两组OGTT 2hC肽均升高，与对照组相比，观察组12周0GTT 2hC肽升高更明显，且具有统计学意义（P〈0．05）。对照组受试者的体重、BMI上升而观察组受试者的体重、腰围、BMI明显下降，且具有统计学意义（P〈0．05）。观察组较对照组12周血糖达标率更优。结论：与胰岛素强化治疗相比，艾塞那肽具有等同的降糖作用且艾塞那肽更明显升高c肽水平，具有显著降低体重作用。

Objective Observation of 40 cases of poor blood sugar control of obese patients with type 2 diabetes application Exenatide and the clinical efficacy ofinsulin intensive therapy for 12 weeks. Methods： between January 2015 and December 2015 in zhongshan hospital affiliated to dalian university of endocrinology40 cases of hospitalized patients with poor blood glucose control in obese patients with type 2 diabetes, Exenatide and insulin enhancing glucose-lowering therapy12 weeks respectively. Result： 4 and 12 weeks after treatment, two groups with statistical difference （P〈 0.05）, were decreased by the FPG, 2hPG OGTr, HbAlc,but fasting C-peptide are increased. Two sets of the above indicators has no statistical difference （P〉0.05）. OGTr 2h C-peptide were increased in both groups,compared with insulin group, 12 weeks of Exenatide OGTI＂ 2h C-peptide increased more obviously, and it has statistical significance （P〈0.05）.Insulin group par-ticipants＂ weight and BMI rise while Exenatide participants＂ weight, waist circumference, BMI decreased obviously and it has statistical significance （P〈0.05）. Af-ter 12 weeks treatment, the Glucose-Target-Rate of Exenatide is better than the insulin group. Conclusion： Compared with the insulin intensive therapy, Exe-natide have equivalent hypoglycemic effect and Exenatide more significantly increased c-peptide levels and has significantly reduced the weight function.