盐酸曲美他嗪对冠心病心力衰竭患者血浆NT—pro-BNP及6分钟步行试验的影响

目的观察盐酸曲美他嗪对冠心病心力衰竭患者心功能的影响。方法：81例符合入选标准的冠心病心力衰竭患者按数字表法被随机均分为治疗组（41例）和对照组（40例）。对照组根据病情给予洋地黄、利尿剂、血管紧张素转化酶抑制剂／血管紧张素受体拮抗剂、0受体阻断剂等治疗，盐酸治疗组在对照组基础上加用盐酸曲美他嗪，疗程6月。结果：两组患者治疗后血浆NT—pro—BNP水平均较治疗前明显降低（P〈0．01），且盐酸治疗组降低幅度较对照组降低更显著（P〈0．05）；两组患者治疗后6 min步行距离均较治疗前显著增加（P〈0．01），且盐酸治疗组增加幅度较对照组更显著（P〈0．01）。结论：盐酸曲美他嗪在常规药物治疗基础上能明显降低心衰患者血浆NT—pro—BNP水平，提高运动耐量。

Objective：To observe influence of trimetazidine on cardiac function in patients with Coronary Heart Disease （CHD）Heart Failur.Methods：According to number table method, 81 patients with coronary heart disease heart failure in our hospital accorded with inclusion standards were randomly and equally divided into trimetazidine group and routine treatment group.According to patient s condition, routine treatment group received digitalis, diuretics, angiotensin convertingenzyme inhibitors/Angiotensin receptor antagonist, B-blocker etc CHF routine treatment.Trimetazidine group additionally received tnmetazldme based on routine treatment.The treatment period was six moths.Plasma N-terminal pro-B-type natriuretie peptide （NT-pro-BNP）level was measured and patients received 6rain walking test （6MWT）before and after treatment.Results：Compared with before treatment, there was significant deerease in plasma NT-pro-BNP level in two groups after treatment（P〈0.01）, eomoared with routine treatment group, there was significant increase in decreasing amplitude of B NP level（P〈0.05）in trimetazidine group;compared with＇before treatment, there was significant increase in 6min walking distance（6MWD）in two groups after treatment（P〈0.01）, compared with routine treat- ment group, there was significant increase in increasing amplitude of 6MWD （P〈0.01） in trimetazidine group.Conclusion：Treatment trimetazidine can significantly reduce plasma NT-pm-BNP level and improve heart function based on routine treatment in patients with heart failure.