奥氮平与奋乃静治疗脑器质性精神障碍的对比研究

目的比较奥氮平与奋乃静治疗脑器质性精神障碍疗效和安全性。方法：选取66例脑器质精神障碍患者。随机分为2组（奥氮平组和奋乃静组），奥氮平组36例，奋乃静组30例，并分别给予药物治疗8周，采用简明精神病评定量表（BPRS）及副反应量表（TESS）评定疗效及不良反应。结果：治疗8周后2组的疗效有显著性差异（P〈0．01），在治疗第4周末奥氮平组总分的减分率显著高于奋乃静组（P〈0．01），奋乃静组肌张力增高、静坐不能发生率显著高于奥氮平组（P〈0．01）。结论：奥氮平治疗脑器质性精神障碍起效快，副反应发生率低，适用于老年患者。

Objective to investigate the olanzapine and perphenazine in the treatment of cerebral organic mental disorder in the efficacy of safety. Methods： a total of 66 cases of cerebral organic mental disorder patients, randomly divided into two groups, olanzapine group 36 eases, perphenazine group of 30 eases, and were given drug treatment for 8 weeks, the brief psychiatric rating scale （BPRS） and symptoms scale （TESS） to assess the curative effect and adverse reactions. Results： 8 weeks after treatment the curative effect of two drugs have significant difference （P 〈 0.01）, total score of olanzapine in thetreatment of 4 weekend group reduction rate was significantly higher than that of perphenazine group （P 〈 0.01）, perphenazine group had a significantly higher incidence of increased muscle tone, akathisia olanzapine group （P 〈 0.01）. Conclusion： olanzapine treatment of cere- bral organic mental disorder work fast, suitable for elderly patients.