急性心肌梗死患者治疗前后血浆ET-1和血清BNP，hs-CRP水平的变化及意义

目的探讨了急性心肌梗死患者治疗前后血浆ET-1和血清BNP，hs—CRP水平的变化及意义。方法：应用放射免疫分析法和酶联免疫分析法对31例急性心肌梗死患者进行了治疗前后血浆ET-1和血清BNP，hs—CRP水平检测并与35名正常健康人作比较。结果：急性心肌梗死患者在治疗前血浆ET-1和血清BNP，hs—CRP水平均非常显著地高于正常人组（P〈0．01），经治疗2周后与正常人比较仍有显著性差异（P〈0．05），且血浆ET-1水平与BNP，hs—CRP水平呈显著正相关（r=0．584 5；0．601 4，P〈0．01）。结论：检测血浆ET-1和血清BNP，hs—CRP水平的变化对急性心肌梗死的诊断，治疗和预后判断具有重要意义。

Objective To explore the Clinical Sigmificance of changes of plasma ET-1 and serum BNP, hs-CRP levels aftertreatment in patients with acute myocardial infarction. Methods： Plasma ET-1 and serum BNP levels （with RIA） , serum hs-CRP levels （with ELISA） were determined in 31 patients with acute myocardial infarction and 35 controls . Results： Beforetreatment, plasma ET-1 and serum BNP, hs-CRP levels were significantly higher than those in controls （P 〈0.01）, aftertreatment for 2 weeks , plasma ET-1 and serum BNP, hs-CRP levels dropped markedly , but remaind obviously higher thanthose in controls （P 〈0.05）. Plasma ET-1 level was positively correlated with serum BNP, hs-CRP levels （r=0.584 5; 0.601 4,P 〈0.01）. Conclusions ： Detection of plasma ET-1 and serum BNP, hs-CRP levels can be helpful is climical important fordiagnosis management and predicting outcome of the diseases.