抗氧化防治急性心肌梗死患者远期心室重构的临床研究

目的研究抗氧化剂”普罗布考”对防治急性心肌梗死血运重建患者远期心室重构的疗效。方法：符合纳入标准的急性sT段抬高型心肌梗死（STEMI）血运重建患者90例，按随机数字表法分为组①和组②。组①：常规冠心病二级预防治疗；组②：冠心病二级预防加“普罗布考”抗氧化治疗。观察指标：（1）各组患者住院期间及1年后心脏彩超结果；（2）各组患者住院期间及3个月后超氧化物歧化酶（SOD）检测结果。结果：1年以后复查心脏彩超结果提示：组①相比于组②发生心脏扩大患者的比率更高（P〈0．05）；3个月后复查SOD水平，组①与前期对比无差异（P〉0．05）。组②与前期对比SOD水平升高（P〈0．05）。结论：氧化应激是导致心梗后进一步心室重构主要因素之一，抗氧化剂“普罗布考”对防治心肌梗死后心室重构的临床疗效显著，值得推广。

Objective To study the antioxidant ＂probucol＂ prevention and treatment of acute myocardial infarction in patientswith long-term revascularization ventricular remodeling effect. Method： met the inclusion criteria for acute ST segment elevationmyocardial infarction （STEMI） revascularization 90 patients were randomly divided into groups and group Group （1）：General secondary prevention of coronary heart disease treatment; group secondary prevention of coronary heart disease plus＂probucol＂ antioxidant therapy. OUTCOME MEASURES： in each group during hospitalization and after one year ofechocardiography results; （2） in each group during hospitalization and after 3 months of superoxide dismutase （SOD） test results.Results： One year after the review echocardiography results suggest that： （1） group occurrence rate compared to the group cardiac enlargement in patients with higher （P 〈0.05）; 3 months after the review SOD levels, contrast with the previous group no significant difference （P〉 0.05）. Comparison with the previous group elevated SOD levels （P 〈0.05）. Conclusion： Oxidativestress is one of the lead after myocardial infarction ventricular remodeling further major factor in anti-oxidants ＂probucor＇clinical efficacy of prevention and treatment of ventricular remodeling after myocardial infarction significantly, worthy ofpromotion.