替加环素对多重耐药鲍曼不动杆菌的体外抗菌活性的相关研究

目的研究替加环素对多重耐药鲍曼不动杆菌的体外抗菌活性，以指导临床合理使用抗生素。方法：收集本院临床标本分离的78株多重耐药鲍曼不动杆菌进行细菌鉴定，并采用纸片扩散法（KB法）对替加环素、美罗培南、头孢哌酮舒巴坦、头孢他啶进行体外药敏试验，观察4种药物的敏感性和耐药性。结果：替加环索对多重耐药鲍曼不动杆菌的敏感性（66．67％）显著高于美罗培南（34．62％）、头孢哌酮舒巴坦（7．69％）、头孢他啶（10．26％），（P〈0．05）；耐药性（0．00％）显著低于美罗培南（43．59％）、头孢哌酮舒巴坦（71．79％）、头孢他啶（69．23％），P〈0．05。结论：替加环素对多重耐药鲍曼不动杆菌有较高的抗菌活性，可作为临床首选治疗药物。

Objective To study the for add ring element of multiple drug resistance of acinetobacter baumannii in vitroantimicrobial activity, and to guide clinical rational use of antibiotics. Methods： collected in our hospital clinical specimens of 78multiple drug-resistant strains of isolated bacteria identification of acinetobacter baumannii, and using the disc diffusion method（KB） to add ring for element, beauty eaecalis, cefoperazone shu temple, cephalosporins he totally susceptibility test in vitro,observe the sensitivity of the four drugs and drug resistance. Results： for add ring element of multiple drug resistance ofaeinetobacter baumannii sensitivity （66.67%） is significantly higher than the United States e.faecalis, and cefoperazone shu bajotham, cephalosporins he organism （34.62%, 7.69%, 10.26%）, （P 〈 0.05）; Resistance （0.00%） was significantly lower than theUnited States e,faecalis and cefoperazone shu temple, and he totally cephalosporin （ 43.59%, 71.79%, 69.23% ） （ P 〈 0.05）.Conclusion： for ring element of multiple drug resistant acinetobacter baumannii have higher antimicrobial activity, can be usedas a cl＇inical choice for treatment.