慢性肾脏病非透析病人矿物质骨代谢紊乱分析

目的分析慢性肾脏病非透析病人矿物质骨代谢紊乱情况。方法：选取2015年03月-2016年03月期间在我院治疗的慢性肾脏病2-5期病人300例，对每期矿物质骨代谢的紊乱发生进行分析，研究骨代谢的紊乱对于慢性肾脏病2—5期病人的影响。结果：病人的iPTH、血磷、25（OH）VitD、尿素氨、iPTH达标率在CKD4、CKD5期比较差异显著，有统计学意义（P〈0．05）；在CKD2—5期中，病人的iPTH、eGFR、肌酐都存在显著差异，有统计学意义①〈O．05）。结论：在CKD2期就会出现25（OH）VitD的水平下降与钙磷代谢的紊乱，需要及时采取钙磷代谢的紊乱干预措施，同时关注25（OH）VitD不足和缺乏管理，防治病人病情进一步恶化。

Objective To analyze the disorder of mineral metabolism in non dialysis patients with chronic kidney disease. Methods： A total of March 2015 - 2016 03 month period in our hospital treatment of chronic kidney disease 2-5 300 patients, the disorder of each bone mineral metabolism occurred were analyzed, the study on bone metabolism disorder for patients in stage 5 chronic kidney disease. Results： The patients of iPTH, serum phosphorus, 25 （OH） VitD and urea nitrogen, serum PTH compliance rate in the theirthyroid, CKD stage 5, the difference significantly, there is statistical significance （P 〈 0.05）; in the CKD2-5, patient iPTH, EGFR, creatinine are exist significant differences, there is significance of statistically significant （P 〈 0.05）. Conclusion： In ckd2 will appear 25 （OH） vitamin D levels decreased with calcium and phosphorus metabolism disorders, the need to take timely and calcium and phosphorus metabolism disorder intervention measures, and pay attention to the 25 （OH） of vitamin D deficiency and lack of management, prevention and treatment of the patient further deterioration.