哌拉西林舒巴坦钠致速发型过敏反应1例

1例78岁老年男性患者，因支气管扩张伴感染入院，给予亚胺培南西司他丁钠联合左氧氟沙星抗感染治疗，经l周的治疗后症状、体征缓解。抗感染方案改为哌拉西林舒巴坦钠治疗，在初次给予该药10 min后即出现心悸、皮肤瘙痒、呼吸困难等不适症状（未伴有发热）。考虑为哌拉西林舒巴坦钠引起的过敏反应，立即停用并给予对症处理后，症状好转。

Objective A 78-year-old male patient, hospitalized due to bronchiectasis with infection, was given imipenem cilastatin sodiumjoint levofloxacin anti-infection treatment, after a week of treatment, symptoms and signs were relieved. Anti-infection program changed tousing piperacillin sulbactam sodium to treat, 10 minutes later of the initial medication, symptoms of palpitations, pruritus, dyspnea （notaccompanied by fever） were appeared. Cconsidering that piperacillin sulbaetam sodium may cause allergic reaction, we stop the-medicationimmediately and give symptomatic treatment, then the symptoms improved.