成都地区脑瘫儿童粗大运动功能分级与脑瘫高危因素的相关性分析

Correlation Between Gross Motor Function and Risk Factors in Children with Cerebral Palsy:an Epidemiology Study in Chengdu

目的 以人群为基础调查和分析脑瘫儿童粗大运动功能分级和脑瘫高危因素是否存在相关性。方法收集成都市行政管辖范围内20个区县残联登记在册的2~12岁脑瘫儿童的脑瘫高危因素和基本信息,应用粗大运动功能分级系统（GMFCS）对粗大运动功能进行分级。采用单因素和多因素logistic回归分析方法进行相关性分析。结果 共调查2~12岁脑瘫患儿333例,男女构成比为1.15∶1,平均（6.32±2.74）岁,6-〈12岁者居多（197例,59.16%）,以痉挛型为主（228例,68.47%）。GMFCSⅠ~Ⅱ级149例（44.74%）,GMFCSⅢ~Ⅴ级184例（55.26%）。纳入30个脑瘫高危因素,最常见的依次为早产（185例,55.56%）、低出生体质量（150例,45.05%）、新生儿缺氧缺血性脑病（104例,31.23%）。经单因素和多因素logistic回归分析,均未发现所纳入研究的脑瘫高危因素与脑瘫儿童GMFCS分级之间具有相关性（P〉0.05）。结论 脑瘫儿童粗大运动功能分级与成都地区脑瘫高危因素之间未见相关性,尚不能用脑瘫高危因素来提示或预测脑瘫患儿粗大运动功能损伤的严重程度。

Objective To investigate the correlation between gross motor function and risk factors in children with cerebral palsy （CP）. Methods We included the children aged 2-12 years old who were diagnosed with CP and registered in Chengdu Federation of Disabled Persons in 20 districts of Chengdu. Gross motor function was estimated by gross motor function classification system （CMFCS）. Risk factors of the CP children were investigated retrospectively. Univariate and multivariate logistic regression analyses were used to analysis the correlation of the CP risk factors and GMFCS grades in the children with CP. Results A total of 333 children were identified with a male to female ratio of 1.15 ： 1 ,an average age of （6.32±2.74） years old, and dominated in 6-〈12 age group （197 cases,59.16%） and spastic CP （228 cases, 68.47%）. Thirty risk factors for CP were included, among which the majors were listed as premature delivery （185 cases, 55.56%）,1ow body mass （150 cases,45.05%） ,and neonatal hypoxic-ischemic encephalopathy （104 cases, 31.23%）. No risk factors of CP were found correlating with GMFCS grades by univariate logistic regression analysis. Stepwise multiple logistic regression analysis showed no risk factors of CP in the regression equation. Conclusion The risk factors of CP can not be used to predict the severity of gross motor function of children with CP.