中西结合治疗对乳腺癌治疗效果、生活质量及预后的评价研究

Therapeutic Effect,Quality of Life and Prognosis of Breast Cancer Patients Treated with Combination of Chinese and Western Medicine

目的:考察中医药联合新辅助化疗治疗乳腺癌的疗效。方法:125例乳腺癌患者均进行新辅助化疗治疗,随机分为对照组(62例)和观察组(63例),对照组进行新辅助化疗治疗,观察组在进行新辅助化疗治疗基础上给予中药方剂口服治疗,两组均在疗程结束后进行手术治疗,对比分析两组治疗效果、病灶转移率及5年内存活率以及中西医结合对患者生活质量的影响。结果对照组治疗总有效率为66.1%(41/62),显著低于观察组的84.1%(53/63),差异具有统计学意义(P<0.05);对照组病灶转移率为75.8%(47/62),明显高于观察组的23.8%(15/63),差异有统计学意义(P<0.05);对照组5年内生存率为14.5%(9/62),显著低于观察组74.6%(47/63),差异有统计学意义(P<0.05);观察组血象检查各项指标均优于对照组,差异均有统计学意义(P<0.05)。观察组不良反应总例数为26例明显少于对照组的46例,差异有统计学意义(P<0.05);观察组生活质量提高、生活质量稳定的例数优于对照组,差异有统计学意义(P<0.05);观察组生存率优于对照组,差异有统计学意义(P<0.05)。结论:将新辅助化疗与传统中药配合使用对于乳腺癌的治疗效果优于单纯使用新辅助化疗,极大增加了手术彻底切除肿瘤的可能性,具有临床价值,值得进一步推广使用。

Objective： To study the curative effect of traditional Chinese medicine and new adjuvant chemotherapy in the treatment of breast cancer. Methods： A total of 125 patients with breast cancer were treated with neoadjuvant chemo- therapy and randomly divided into control group （62 cases） and observation group （63 cases）. The control group were treated by neoadjuvant chemotherapy and the observation group were given neoadjuvant chemotherapy treatment on the ba- sis of traditional Chinese medicine oral treatment. The two groups were treated with surgery after the course of treatment. The therapeutic effect of the two groups, the rate of metastasis and the 5 - year survival rate were compared and analyzed. At the same time the influence of combination of Chinese and western medicine on patients quality of life was observed. Results： The control group＇ s response rate was 66.1% in the treatment group （41/62）, significantly lower than 84.1% in the observation group （53/63） and the difference was statistically significant （ P 〈 0., 05 ）. The control group＇ s shift focus was 75.8% （47/62） ,significantly higher than 23.8% in the observation group （15/63）. The difference was sta- tistically significant （P 〈 0.05 ）. The 5 -year survival rate of the control group was 14.5 % （9/62）, significantly lower than 74.6% in the observation group （47/63） and the difference was statistically significant （ P 〈 O. 05 ）. The number of adverse reactions was 26 cases, obviously lower than the control group＇ s 46 cases and the difference was statistically sig- nificant （/9 〈 0.05 ）. The observation groups rate of improvement and stabilization was 80.95% , significantly higher than 13.19% of the control group and the difference was statistically significant （P 〈0.05 ）. The total effect rate of ＇the obser- vation group was 63.49% ,significantly higher than 53.96% of the control group and the difference was statistically sig- nificant （/9 〈 0.05 ）. And the progression of disease in the observation group was 4.76% and the control group＇s 17.46% and the difference was statistically significant （ P 〈 0. 05 ）. Conclusion ： The effect of neoadjuvant chemotherapy combined with traditional Chinese medicine on the treatment of breast cancer is better than the simple use of neoadjuvant chemother- apy. The possibility of radical resection of the tumor was greatly increased. It has clinical value and is worth to further promote the using.