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慢性心力衰竭患者肺部感染血清MMPs的变化研究 被引量:9

Change of serum MMPs in chronic heart failure patients with pulmonary infection
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摘要 目的探讨慢性心力衰竭合并肺部感染患者血清基质金属蛋白酶(MMPs)的变化,为临床诊治提供参考依据。方法选取2013年1月-2015年8月诊治的单纯慢性心力衰竭(对照组)、慢性心力衰竭合并肺部感染(观察组)各80例,采用酶联免疫吸附法(ELISA)对血清MMP-2、MMP-9、MMP-10水平进行检测,采用SPSS17.0软件进行统计分析。结果观察组患者血清MMP-2、MMP-9、MMP-10水平分别为(144.78±35.67)μg/ml、(165.73±46.90)μg/ml、(50.28±9.77)pg/ml,高于对照组,组间比较差异有统计学意义(P<0.05);对照组、观察组患者血清MMP-2、MMP-9、MMP-10水平Ⅳ级高于Ⅱ、Ⅲ级,Ⅲ级高于Ⅱ级,组内比较差异有统计学意义(P<0.05),血清MMP-2、MMP-9、MMP-10水平观察组中Ⅱ、Ⅲ、Ⅳ级水平均高于对照组Ⅱ、Ⅲ、Ⅳ级,组间比较差异有统计学意义(P<0.05)。结论慢性心力衰竭合并肺部感染患者血清MMP-2、MMP-9、MMP-10水平表达上调,肺部感染的发生可加重患者心功能及左心室重构恶化。 OBJECTIVE To explore the change of serum matrix metalloproteinases(MMPs)in chronic heart failure patients complicated with pulmonary infection so as to provide guidance for clinical diagnosis and treatment.METHODS Totally 80 patients with single chronic heart failure and 80 chronic heart failure patients complicated with pulmonary infection who were treated from Jan 2013 to Aug 2015 were enrolled in the study and were respectively assigned as the control group and the observation group.The levels of serum MMP-2,MMP-9,and MMP-10 were detected by using enzyme-linked immunosorbent assay(ELISA),and the statistical analysis was performed with the use of SPSS17.0software.RESULTS The levels of serum MMP-2,MMP-9,and MMP-10 of the observation group were respectively(144.78±35.67)μg/ml,(165.73±46.90)μg/ml,and(50.28±9.77)pg/ml,significantly higher than those of the control group(P〈0.05).The levels of serum MMP-2,MMP-9,and MMP-10 of the gradeⅣ patients were significently higher than those of the gradeⅡ orⅢ patients,the levels of the gradeⅢ patients were significently higher than those of the gradeⅡ patients(P〈0.05).The levels of serum MMP-2,MMP-9,and MMP-10 of the grade Ⅱ,Ⅲ,or Ⅳ patients in the observation group were significently higher than those of the gradeⅡ,Ⅲ,orⅣ patients in the control group(P〈0.05).CONCLUSION The levels of serum MMP-2,MMP-9,and MMP-10 are elevated in the chronic heart failure patients complicated with pulmonary infection,and the pulmonary infection may aggravate the deterioration of cardiac function and left ventricular remodeling.
出处 《中华医院感染学杂志》 CAS CSCD 北大核心 2016年第17期3915-3917,共3页 Chinese Journal of Nosocomiology
基金 河南省科技厅基金资助项目(2012398347HW)
关键词 慢性心力衰竭 肺部感染 基质金属蛋白酶 Chronic heart failure Pulmonary infection Matrix metalloproteinase
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参考文献7

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二级参考文献6

  • 1中华医学会心血管病分会,中华心血管病杂志编辑委员会.中国心力衰竭诊断和治疗指南2014.中华心血管病杂志,2014,42:98-122.
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  • 3MeMurray JJ, Adamopoulos S, Anker SD, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collahoration with the Heart Failure Association (HFA) of the ESC. Eur Heart J, 2012, 33: 1787-1847.
  • 4Swedberg K, Komajda M, B6hm M, et al. Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study. Lancet, 2010, 376: 875-885.
  • 5中华医学会心血管病分会,中华心血管病杂志编辑委员会.慢性心力衰竭诊断和治疗指南.中华心血管病杂志,2007,35:1076-1095.
  • 6Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA Guideline for the managment of heart failure: a report of the American College of CardMogy Foundation/American Heart Association Task Force on Practice Guidelines. Circulation, 2013, 128: e240-e327.

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