降阶梯方案用于治疗重症获得性下呼吸道感染临床疗效分析

Clinical effect of de-escalation scheme on treatment of severe acquired lower respiratory tract infections

目的探讨降阶梯方案用于重症获得性下呼吸道感染患者治疗中的临床效果,为临床治疗提供依据。方法选取2013年10月-2015年6月医院收治的88例重症获得性下呼吸道感染患者,随机分为观察组和对照组,各44例,对照组患者给予传统治疗,观察组患者采用降阶梯方案进行治疗,统计两组患者治疗后的感染控制情况和临床疗效。结果观察组44例患者治疗有效37例,有效率为84.09%,对照组44例患者治疗有效28例,有效率为63.64%,两组比较差异有统计学意义(P<0.05);观察组平均感染控制时间为(7.36±2.55)d,对照组为(12.74±3.73)d,两组比较差异有统计学意义(P<0.05)。结论临床治疗重症获得性下呼吸道感染患者采用降阶梯方案临床疗效显著,可在短时间内有效控制病情发展,治疗方案针对性强,值得临床推广。

OBJECTIVE To explore the clinical effect of de-escalation schema on treatment of patients with severe acquired lower respiratory tract infections so as to provide guidance for clinical treatment.METHODS A total of 88 patients with severe acquired lower respiratory tract infections who were treated in the hospital from Oct 2013 to Jun 2015 were enrolled in the study and randomly divided into the observation group and the control group,with44 cases in each group.The control group was given the conventional therapy,and the observation group was treated with de-escalation scheme.The situation of control of the infections and the clinical effects were observed and compared between the two groups of patients.RESULTS The treatment was effective in 37 of 44patients in the observation group,with the effective rate 84.09%,the treatment was effective in 28 of 44patients in the control group,with the effective rate 63.64%,and there was significant difference between the two groups（P〈0.05）.The average time of control of infections was（7.36±2.55）days in the observation group,（12.74±3.73）days in the control group,and there was significant difference between the two groups（P〈0.05）.CONCLUSIONThe deescalation scheme can achieve significant clinical effect on treatment of the patients with severe acquired lower respiratory tract infections and effectively control the development of illness condition in a short period of time;the treatment scheme is highly targeted and is worthy to be promoted in the hospital.