摘要
目的探讨黄连素对利培酮单药治疗的精神分裂症患者胰岛素抵抗与血清细胞因子水平的影响。方法将64例利培酮单药治疗的精神分裂症患者随机分为研究组(合并黄连素治疗)31例和对照组(合并安慰剂治疗)33例,测定2组患者治疗前及治疗12周后的空腹血糖(FBG)、空腹胰岛素(Fins),采用稳态模型公式计算胰岛素抵抗指数(HOMA-IR)。采用酶联免疫吸附法测定血清白细胞介素(IL)-1β、IL-6、肿瘤坏死因子(TNF)-α水平。结果研究组治疗后的FBG、Fins、HOMA-IR、IL-1β、IL-6、TNF-α水平较自身治疗前和对照组治疗后均显著降低(P<0.05);而对照组治疗后较治疗前FBG水平则显著升高(P<0.01),IL-1β、IL-6、TNF-α水平降低(P<0.01),Fins、HOMA-IR水平无明显变化(P>0.05)。研究组患者HOMA-IR与血清IL-1β、IL-6、TNF-α均呈正相关(r分别为0.316、0.351及0.401,P<0.01)。结论黄连素能显著降低利培酮单药治疗的精神分裂症患者FBG、Fins、HOMA-IR、IL-1β、IL-6、TNF-α水平,且HOMA-IR水平与IL-1β、IL-6、TNF-α密切相关。
Objective To explore the impact of berberine on serum levels of insulin resistance and cytokines inschizophrenia patients treated with risperidone. Methods Sixty-four schizophrenia patients treated with risperidone wererandomized to berberine group （n=31） and control group （n=33）. The fasting plasma blood glucose （FBG） and fasting insulin（Fins） were detected before and after treatment in two groups. The homeostasis model assessment for insulin resistance（HOMA-IR） was calculated. The serum levels of interleukin （IL）-1β, IL-6, tumor necrosis factor-alpha （TNF-α） wereevaluated by enzyme linked immunosorbent assay before and after the treatment. Results Compared with control group andpre-treatment group, the levels of FBG, Fins, HOMA-IR, IL- 1β, IL-6 and TNF-α were significantly decreased aftertreatment in berberine group （P 〈 0.05）. The FBG level was significantly higher, the levels of IL-1β, IL-6 and TNF-α weresignificantly lower, after treatment in control group （P 〈 0.01）. There were no significant changes in Fins and HOMA-IRafter treatment （P 〉 0.05）. There was positive correlation between HOMA-IR and IL-1β, IL-6 and TNF-α in berberinegroup （r=0.316, 0.351 and 0.401, P 〈 0.01）. Conclusion Berberine can significantly decrease FBG, Fins, HOMA-IR, IL-1β, IL-6 and TNF-α levels in schizophrenia patients treated with risperidone. The HOMA-IR level is closely correlatedwith IL-1β, IL-6 and TNF-α levels.
出处
《天津医药》
CAS
2016年第9期1143-1146,共4页
Tianjin Medical Journal
基金
天津市安定医院院级课题基金资助(1507)
