盐酸纳美芬治疗急性脑梗死的临床观察

Clinical observation of nalmefene hydrochloride treatment on patients with acute cerebral infarction

目的观察盐酸纳美芬对急性脑梗死患者的影响,评估其临床疗效和安全性。方法将63例急性脑梗死患者随机分为观察组(n=31)和对照组(n=32),所有病例均采用神经内科急性脑梗死常规治疗方案,观察组在此基础上加用盐酸纳美芬治疗。比较治疗前后两组的神经功能缺损评分与疗效情况。结果治疗14 d后,观察组神经功能缺损评分优于对照组(P<0.05);观察组临床治疗总有效率优于对照组,差异有统计学意义(P<0.05)。结论盐酸纳美芬能改善急性脑梗死患者的神经功能情况,提高患者的预后水平。

Objective In order to evaluate the clinical efficacy and safety, we would use Nalmefene hydrochloride treatment on patients with acute cerebral infarction, seeing whether there is the effect on the patients. Methods Firstly, we randomly divided 63 patients with acute cerebral infarction into two groups, 31 patients in the observation group and 32 patients in the control group. Secondly, all patients were treated with conventional therapy of acute cerebral infarction neurology program. Based on the treatment, we also use Nalmefene hydrochloride on the patients of observation group. At last, we would compare the results of two groups＇ patients. Results After 14 days treatment, there is a improvement of neurological disability in both of the two groups after the treatment（P〈0.05）. However, the improvement is more obvious with observation group. There is a statistical significance of the difference of the score in the improvement of neurological disability after the treatment of the two groups. Conclusion Nalmefene hydrochloride does improve neurological condition in patients with acute cerebral infarction, which might also improve the expectation of patients.