DNA免疫吸附治疗系统性红斑狼疮疗效观察及护理体会

Clinical effect of DNA immunoadsorption therapy in treatment of systemic lupus erythematosus and related nursing management

目的探讨应用DNA免疫吸附治疗系统性红斑狼疮(SLE)的疗效及护理体会。方法 21例SLE患者进行48次免疫吸附治疗,治疗过程中针对患者心理、饮食、血管通路、不良反应和并发症等多方面实施护理干预。结果免疫吸附治疗后,21例患者纳差和乏力症状改善,免疫吸附治疗2周后复查血清抗双链DNA抗体水平(ds-DNA)较治疗前显著下降(P<0.01)。治疗期间主要不良反应为2例血小板减少。结论 DNA免疫吸附是治疗SLE的重要手段之一,合理的护理措施是保障治疗顺利的关键。

Objective To observer the clinical effect of DNA immunoadsorption therapy in treatment of systemic lupus erythematosus （ SLE） and to summarize the nursing management. Methods A total of 21 SLE patients undergoing 48 times of DNA immunoadsorption therapy were included in this study. Nursing measures were provided mainly focusing on psychological states, diet, vascular access ,side reaction and complication of patients. Results The symptom such as anorexia and fatigue were improved in all 21 SLE patients after DNA immunoadsorption therapy. The serum level of anti-ds- DNA autoantibody was decreased 2 weeks after treatment compared with that before treatment （P 〈0. 01） . The main side reaction was thrombocytopenia, which was reported in two cases during observation period. Conclusion DNA immunoadsorption therapy is an important way of treating SLE, and proper nursing measures should be applied to ensure the therapeutic effect.