高温裂解蓖麻油合成10-羟基癸酸研究

Research on synthesis of 10-hydroxy decanoic acid by scission using castor oil at high temperature

以碱和蓖麻油为原料,在高温下碱催化裂解合成10-羟基癸酸,通过对裂解反应的溶剂体系、反应时间、碱类型和碱用量研究,确立了合成10-羟基癸酸的最佳反应条件:邻甲酚与仲辛醇(2.8/1,v/v)为反应溶剂,氢氧化钠为裂解催化剂(60g),反应温度180-200℃,反应时间5小时。在最佳条件下,10-羟基癸酸产率可高达71%,目标产物经HRMS和NMR证实,与文献一致。

10-hydroxy decanoic acid was synthesized by scission of strong base and castor oil at high temperature,which was investi-gated from the viewpoints of reaction solvent systems,reaction time,and the type and amount of base. The optimum conditions were as follows：reaction solvent systems： o-cresol and sec-octyl alcohol（v/ v = 2. 8 ： 1 ） ,N aO H （6 0 g ） , reaction t ime： 3 0 0m in , reaction tem-perature ： 180-200 ,the yield was 71%. The structure of synthetic product was characterized by HRMS and NMR.