粪菌移植与炎症性肠病

Fecal Microbiota Transplantation and Inflammatory Bowel Disease

炎症性肠病(IBD)是一组发病机制尚未明确的肠道炎性疾病,包括克罗恩病(CD)和溃疡性结肠炎(UC)。研究显示肠道菌群紊乱与IBD的发生、发展密切相关。目前粪菌移植(FMT)被视为一种特殊的器官移植,已应用于治疗IBD、难辨梭状芽孢杆菌感染、肠易激综合征、代谢综合征等疾病。本文就FMT与IBD的关系作一综述。

Inflammatory bowel disease（ IBD）,comprising Crohn＇s disease（ CD） and ulcerative colitis（ UC）,is a chronic intestinal inflammatory disease and its etiology has not yet been clarified. Studies showed that intestinal microbiota disorder is closely associated with the development and progression of IBD. Currently,fecal microbiota transplantation（ FMT） is considered as a special organ transplantation and used in treatment of IBD,Clostridium difficile infection,irritable bowel syndrome,metabolic syndrome,etc. This article reviewed the relationship between FMT and IBD.