抵当汤治疗早期老年痴呆临床研究

The Clinical Research into Early Senile Dementia Treated with Didang Decoction

目的:观察抵当汤治疗早期老年痴呆的临床疗效。方法:将80例早期老年痴呆患者随机均分为对照组和观察组各40例,对照组给予盐酸多奈哌齐片治疗,每日1次,每次5 mg,睡前服用,连续服用4周后改为每次10 mg,每日1次,睡前服用。续服12周。观察组在对照组治疗的基础上采用抵当汤原方治疗,日1剂,连服16周。观察两组患者临床疗效及对MMSE、ADL、CDR评分的影响。结果:两组治疗后MMSE、ADL评分均较治疗前明显改善(P<0.05),且组间比较差异显著(P<0.05);两组治疗后CDR分值较治疗前无明显改善(P>0.05);对照组有效率为75.00%,观察组有效率为85.00%,两组有效率比较,差异有显著性(P<0.05)。结论:抵当汤治疗早期老年痴呆疗效显著,可改善患者认知功能和日常自理能力。

Objective： To observe the clinical curative effect of Didang Decoction（ DDD） on early senile dementia. Methods：Eighty patients with early senile dementia were randomly divided into the observation group and the control group,with 40 cases in each group. The ones in the control group were given Donepezil Hydrochloride for treatment,once a day,and 5mg each time before sleep; After 4 weeks continuously,change to 10 mg each time and once a day before sleep,lasting for 12 weeks; while the ones in the observation group were added DDD based on the treatment of the control group. Then the clinical curative effects,the influence of DDD on MMSE,ADL and GDS scores of the two groups were observed. Results： After the treatment,the MMSE and ADL scores of the two groups were greatly improved（ P〈0. 05）,and the difference between the two groups had statistical significance（ P〈0. 05）. After the treatment,CDR scores of the two groups had no obvious improvement（ P〉0. 05）; The effective rate of the control group was 75. 00%,while that of the observation group was 85. 00%; And the difference between them had significance（ P〈0. 05）. Conclusion： DDD has a remarkable clinical curative effect on early senile dementia,can improve the cognitive function and daily self-care ability of patients.