中医药对甲型流行性感冒病毒核酸动态变化的影响

The Influence of Traditional Chinese Medicinal Herbs on the Dynamic Changes of Nucleic Acid of Influenza A Virus

目的:评价中医药治疗甲型流行性感冒(简称甲流)的抗病毒疗效。方法:收集102例甲型流感患者,随机分为中医组与西医组,两组均给予一般支持治疗,抗病毒西药由医师按临床实际情况应用,中医组加用疏风散寒解毒中药治疗。结果:96例患者(中医组56例,西医组40例)为甲型流感病毒核酸阳性,用药后第3天流感病毒阴转率中医组为60.71%,西医组为62.5%;第5天流感病毒阴转率中医组为75.00%,西医组为77.50%;第7天流感病毒阴转率中医组为91.07%,西医组为92.5%;两组核酸阴转率各个时间点比较无统计学差异,P均>0.05;中医组56例患者,有22例患者使用了抗病毒药物,占本组的39.29%;西医组40例患者,有34例患者使用了抗病毒药物,占本组的85.00%,两组抗病毒药物使用率比较,差异性极显著(P<0.01);中医组有13例患者使用了奥司他韦,占本组的23.21%,西医组有24例使用奥司他韦,占本组的60.00%,两组奥司他韦使用率比较,差异性也极显著(P<0.01)。结论:疏风散寒解毒法治疗甲流的抗病毒疗效与西药相当。

Objective： To evaluate the antiviral clinical curative effect of influenza A. Methods： One hundred and two patients with influenza A were chosen and randomly divided into the TCM group and the Western medicine group. Both groups were given general supportive treatment,antiviral Western medicine is given according to clinical condition by the doctors,and the ones in the TCM group were added traditional Chinese medicinal herbs for dispersing wind and wind and removing toxin. Results： Among the96 patients（ 56 cases in the TCM group and 40 cases in the Western medicine group diagnosed with influenza A nucleic acid positive,after 3 days＇ treatment,influenza negative conversion rate of the TCM group was 60. 71%,while that of the Western medicine group was 62. 5%; After 5 days＇ treatment,influenza negative conversion rate of the TCM group was 75. 00%,while that of the Western medicine group was 77. 50%; After 7 days ＇ treatment,influenza negative conversion rate of the TCM group was91. 07%,while that of the Western medicine group was 92. 50%; Nucleic acid negative conversion rate of the two groups in each time point had no statistical significance（ all P〈0. 05）. Among the 56 cases of the TCM group,22 cases（ 39. 29%） used antiviral medicine,while 34（ 85. 00%） of 40 cases in the Western medicine group did; And the difference in the antiviral medicine use rate of the two groups had obvious significance（ P〈0. 01）. 13 cases（ 23. 21%） used Oseltamivir,while 24（ 60. 00%） of40 cases in the Western medicine group did; And the difference in the antiviral medicine use rate of the two groups had obvious significance（ P〈0. 01）. And the difference in the Oseltamivir use rate of the two groups had obvious significance（ P〈0. 01）.Conclusion： Method of dispersing wind and removing cold and toxin has the same antiviral curative effect as the Western medicine in treating influenza A.