由联芳基羧酸合成联芳基噁唑啉的方法

Synthesis Method of Biaryl Oxazoline From Biaryl Acids

1951年,美国一篇专利说明可以由乙酸和氨基乙醇类化合物缩合成噁唑啉环,引起了科学工作者的广泛探索,相继有一些利用这类反应制备噁唑啉环的报道。联芳基噁唑啉也可以由联芳基羧酸与氨基醇经过关环合成得到。主要讲述了近年来以联芳基羧酸和手性氨基醇为原料合成联芳基噁唑啉的一系列报道的方法。

In 1951, a patent from the United States showed that oxazoline could be prepared from acetic acid and amino alcohol compounds, which aroused wide exploration of scientific workers, then there were some reports about use of this type of reaction for preparation of oxazoline. Biaryl oxazoline can also be obtained from aryl carboxylic acids and amino alcohols by cyclization. In this article, a series of synthesis methods of biaryl oxazoline from biaryl acids and aryl carboxylic acids were introduced.