重型和中间型β-地中海贫血患儿输注洗涤红细胞的效果比较

A Comparative Investigation of the Therapuetic Effect in Children with β-thalassemia and Received Transfusion of Washed Erythrocytes

目的分析重型和中间型β-地中海贫血患者输注洗涤红细胞后疗效的差别.方法选取两型患儿共23例,在输血背景相同的条件下,调查相同年龄阶段（ 3-4岁）两组各21例次输注洗涤红细胞前后的血红蛋白水平,比较两型患儿输 血后血红蛋白增量的差异,以及是否发生输血不良反应.结果42例次输血均未发生输血不良反应,同年龄阶段重型β-地中海贫血患儿每输1 U洗涤红细胞后每千克体重血红蛋白增量较中间型地贫患儿相比偏低（P〈0.05 ）.结论在同年龄阶段输 注同量的洗涤红细胞,重型β-地中海贫血患者由于其病情相对较重,导致Hb提升水平比中间型患者低,同时临床在应用洗 涤红细胞时应确保达到目标Hb水平和安全输血双重目标的实现.

Objective To analyze the effect of washed red blood cells（wRBC） transfusion in treatment of children with severe or intermediate β-thalassemia. Methods Twenty-three children at the age of 3？4 were selected and all of them had the same blood transfusion experience. Hemoglobin levels were tested in the children who sufferred from severe or moderatep-thalassemia and underwent 21 times of blood transfusion with wRBC in each type of disease. and frequency of adverse effects of transfusion was observed. Results All the children investgated showed no adverse transfusion reaction. Children with severe type of β-thalassemia exhibited a lower increase of hemoglobin [ （1.62 ± 0.26） g/L per kg] than those with moderate type of the disease[ （1.17 ± 0.23） g/L per kg] after use of one unit of wRBC （P〈0.05 ） . Conclusion Hemoglobin level improvement in the children with severe type of β-thalassemia is not remarkable when compared with those who have moderate type of the disease after wRBC transfusion. Clinically, a relative high level of hemoglobin, and transfusion safety as well, should be ensured during wRBC transfusion.