MMP-9/TIMP-1与川崎病发病机制关系的研究进展

Advances in Research of the Relationship between MMP-9/TIMP-1 and Pathogenesis of Kawasaki Disease

川崎病（KD）是一种急性、自限性的全身性血管炎,好发于6个月~5岁的儿童,可导致严重的心血管并发症,是儿童后天获得性心脏病最常见的原因。流行病学调查表明,KD的发病率在亚裔人群中稳步的增长,严重影响未来儿童的公共健康,然而其病因和发病机制尚不完全清楚。基质金属蛋白酶-9（MMP-9）/金属蛋白酶组织抑制剂-1（TIMP-1）是调节细胞外基质（ECM）合成与降解的主要酶类,研究MMP-9/TIMP-1与KD发病机制的关系对了解KD的发病机制、预防心血管系统并发症起重要作用。

Kawasaki disease （ KD ） is characterized with acute and serf-limited systemic vascujitis, occurs predominantly in children between 6 months to 5 years of age.It can lead to devastating cardiovascular complications and become the commonest cause of acquired pediatric heart disease.Epidemiological investigation revealed steady increases in the prevalence of KD in Asian descent, seriously affect public health in children in the near future. However, the etiology and pathogenesis of KD have yet to be known.MMP-9/TIMP-1 is a main enzyme in the regulation of the extracellular matrix synthesis and degradation.To study the relationship between MMP-9/TIMP- 1 and pathogenesis of KD is important in the understanding of KD pathogenesis and prevention of cardiovascular complications.