载脂蛋白E基因多态性与动脉粥样硬化性脑梗死关系的Meta分析

Meta Analysis of Relationship between Apo E Gene Polymorphisms and Atherosclerotic Cerebral Infarction

目的:采用Meta分析的方法探讨载脂蛋白E(Apo E)基因多态性与动脉粥样硬化性脑梗死的关系。方法:双人独立全面检索在中国人群中开展的载脂蛋白E基因多态性与动脉粥样硬化性脑梗死关系的文献,采用固定或随机效应模型合并效应值计算95%置信区间,绘制森林图并进行异质性检验。结果:共纳入12篇符合要求文献,研究发现与携带ε3/ε3野生基因型的个体相比,携带ε4基因型的个体动脉粥样硬化性脑梗死的风险显著增加(OR=3.06,95%CI:1.66,5.64),并未发现携带ε2基因型会降低动脉粥样硬化性脑梗死的发生风险(OR=1.20,95%CI:0.89,1.64)。结论:携带Apo Eε4基因型的个体是动脉粥样硬化性脑梗死的高危人群。

Objective： To examine the relationship between ApoE gene polymorphisms and risk of Atherosclerotic cerebral infarction （ACI）by Meta analysis.Method： Two researchers independently reviewed the literature which examined the relationship between ApoE gene polymorphisms and risk of ACI.We used fix or random effect models to combine the odds ratio and 95% confidence intervals.Forest plots were used to show each study＇s effect and the combined effect while funnel plot and egger test were used to test the heterogeneity. Result： A total of 11 case-control studies were included into the final analysis.Compared with the ε3/ε 3 wild genotype, individuals with ε 4 genotype had significant higher risk of AIC （ OR=3.06, 95%CI： 1.66, 5.64 ） . However, we didn＇t find individuals with ε 2 genotype had reduced risk ofACI （ OR=1.20, 95%CI：0.89, 1.64 ） . Conclusion： Individuals with ApoE ε 4 genotype may at particularly high risk of ACI.