C反应蛋白、D-二聚体及降钙素原评估急性胰腺炎严重程度的临床价值

Clinical Value of C-reactive Protein,D-dimer and Procalcitonin in Evaluating Severity of Acute Pancreatitis

目的:探讨C反应蛋白(CRP)、D-二聚体及降钙素原(PCT)对急性胰腺炎(AP)病情严重程度评估的临床价值。方法:收集2014年1月-2015年12月笔者所在医院收治的急性胰腺炎患者156例,其中轻症急性胰腺炎组81例,中度重症急性胰腺炎组39例,重症急性胰腺炎组36例,检测血清CRP、D-二聚体及降钙素原水平,进行BISAP、CTSI评分,分析CRP、D-二聚体、降钙素原与BISAP评分、CTSI评分之间的相关性。结果:血清CRP、D-二聚体及降钙素原在各组间均不相同,SAP组>MSAP组>MAP组,差异均有统计学意义(P<0.05);血清CRP、D-二聚体、降钙素原均与BISAP评分呈正相关(r值分别为0.747、0.743、0.663,P<0.05);血清CRP、D-二聚体、降钙素原均与CTSI评分呈正相关(r值分别为0.903、0.682、0.709,P<0.05)。结论:血清CRP、D-二聚体及降钙素原与急性胰腺炎严重程度呈正相关,对判断AP严重程度具有重要临床价值。

Objective： To explore the clinical value of C-reactive protein（CRP）, D-dimer and procalcitonin in evaluating severity of acute panereatitis（AP）.Method： The data from 156 patients with acute pancreatitis, who admitted into our hospital from January 2014 to December 2015 were collected, including mild acute pancreatitis（MAP） group（n=81）, moderately severe acute panereatitis（MSAP） group（n=39） and severe acute panereatitis（SAP） group（n=36）. The levels of serum C-reactive protein, D-dimer and procalcitonin were measured, the scores of BISAP and CTSI were obtained.The correlations between serum C-reactive protein, D-dimer, procaleitonin and BISAP scores, CTSI scores were analyzed.Result： The levels of serum C-reactive protein, D-dimer and proealcitonin were all significantly different in the different groups（P〈0.05）.The levels of serum C-reactive protein, D-dimer and procaleitonin were all the highest in SAP group, followed by MSAP group, the lowest in MAP group.Serum C-reactive protein, D-dimer and procaleitonin were all positively correlated with BISAP scores（r=0.747, 0.743, 0.663, P〈0.05）.Serum C-reactive protein, D-dimer and procalcitonin were all positively correlated with CTSI scores（r=-0.903, 0.682, 0.709, P〈0.05）.Conclusion： Serum C-reactive protein, D-dimer and proealcitonin are all positively correlated with the severity of acute panereatitis, they have important clinical value in judging the severity of AP.