骨化三醇联合缬沙坦减少IgA肾病尿蛋白的疗效观察

Effect of three alcohol combined with valsartan on reducing urinary protein in IgA nephropathy

目的:探讨骨化三醇联合缬沙坦减少Ig A肾病尿蛋白的疗效分析。方法:选取收治的75例Ig A肾病患者,将其随机分为三组,组1患者服用骨化三醇胶丸,组2患者服用缬沙坦胶囊,组3患者服用骨化三醇胶丸联合颉沙坦胶囊,治疗4个月后,比较三组患者治疗前后24 h尿蛋白、血尿素氮(BUN)、转化生长因子β1(TGF-β1)、血肌酐24 h(Scr)、血钙(Ca)、血钾(K)及血磷(P)的含量变化。结果:与治疗前相比,经治疗后各组患者的24 h尿蛋白及TGF-β1含量均显著降低,差异有统计学意义(P<0.05);治疗后与组1组2比较,组3患者的24 h尿蛋白及TGF-β1含量比较,差异有统计学意义(P<0.05);三组患者治疗前后血尿素氮(BUN)、血肌酐24 h(Scr)、血钙(Ca)、血钾(K)及血磷(P)的含量比较,差异无统计学意义(P>0.05)。结论:骨化三醇胶丸联合颉沙坦胶囊治疗Ig A降低尿蛋白及TGF-β1的作用强于单用一种药,且对血尿素氮(BUN)、血钙、血钾及血磷无显著影响。

Objective To observe the effect of calcitriol plus Chastain treatment for IgA nephropathy. Method 75 patients with IgA nephropathy were selected, they were randomly divided into 3 groups,the first group were taken with calcitriol capsule, the second group were taken with Chastain capsule, the third group were taken with calcitriol plus Chastain, after treating for 4 months, the changes of 24 h urine protein, blood urea nitrogen （ BUN）, transforming growth factor betal （ TGF - β1 ）, serum creatinine （ Scr）, calcium（Ca） ,potassium （K） and phosphorus （P）were measured. Results Compared with before treatment, the content of 24 h urine protein and TGF - β1 were significantly decreased, the difference was statistically significant （ P 〈 0. 05） ; after treatrment, compared with 1st group and 2ud group,the 24 h urine protein and TGF -β1 of the third group was lower,the difference was statistically sig- nificant （P 〈 0. 05 ） ;there was no significant difference between three groups in blood urea nitrogen （ BUN）, serum creatinine （ Scr ）, calcium （ Ca） ,potassium （K） and phosphorus （P）,the difference wasn＇t statistically significant （ P 〉 0. 05）. Conclusion Calcitriol plus Chastain can significantly reduce the level of urinary protein in patients with IgA nephropathy, and was more effective than single drug used, have no significant on serum reatinine （Scr） , calcium （Ca）, potassium （K） and phosphorus （P）.