评价复方多粘菌素B软膏治疗细菌性皮肤病的有效性和安全性

Evaluation of efficacy and safety of compound polymyxin B cream in the treatment of bacterial skin infections

目的:分析评价复方多粘菌素B软膏治疗细菌性皮肤病的有效性和安全性。方法:选取72例细菌性皮肤病患者,根据随机原则分成参照组和研究组。其中36例参照组患者予以盐酸环丙沙星软膏治疗,36例研究组患者予以复方多粘菌素B软膏治疗。连续治疗1周,对比两组患者治疗的有效性和安全性。结果:对相关数据进行统计分析发现,研究组总有效率跟参照组相似,均比较高,其中,参照组为86.11%,研究组为83.33%(P=0.283)。不良反应研究组仅1例出现轻度烧灼感(2.78%),参照组仅1例出现轻度瘙痒(2.78%),组间比较,差异无统计学意义(P>0.05)。结论:予以复方多粘菌素B软膏治疗细菌性皮肤病具有治疗效果好、安全性高等优势,临床可推荐使用。

Objective To evaluate the efficacy and safety of compound polymyxin B cream in the treatment of bacterial skin infections. Method 72 patients with bacterial skin infections were randomly divided into two groups, and differently treated with hydrochloric ciprofloxacin cream（ control group） and compound polymyxin B cream（ treatment group） for 7 days. There were 36 eases in each groups ,and both groups were compared by evaluating the efficacy and safety. Results The overall response rate was similarly high in the two groups. The total effective rate were 86. 11% in the control group and 83.33% in the treatment group（P = 0. 283）. The adverse event was only occurred in the treatment group（2. 78% ） showed mild skin burning sensation,and 1 case showed partly skin pruritus in the control group （2. 78% ）, there was no statistical significance between the two groups （P 〉 0. 05 ）. Conclusion Compound polymyxin B cream is safety and effective in treatment of bacterial skin infections,which is worthy of recommendation.